Articles Tagged With:
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Oral Penicillin Challenge Found to Be Noninferior to Skin Testing Followed by Oral Challenge in Low-Risk Patients with Reported Penicillin Allergy
A multicenter, randomized clinical trial that compared direct oral penicillin challenge in low-risk patients to skin testing followed by oral challenge found no significant differences. Direct oral penicillin challenge appears to be a safe and effective way to delabel a penicillin allergy.
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Oral Antibiotics in Endocarditis: Hitting the Target
Pharmacodynamic/pharmacokinetic analysis of patients in the POET study provides understanding of the efficacy of intravenous-to-oral stepdown antibiotic therapy in patients with endocarditis.
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Increasing Reports of Severe Group A Streptococcal Infection
Around the world, rates of severe illness due to group A Streptococcus are increasing. Possible explanations for the increase include immunity-altering, post-pandemic changes in exposure to respiratory pathogens, as well as the emergence of new pathogenic M strains of Streptococcus.
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Fatal Flea-Borne Typhus in California
Three fatal cases of flea-borne typhus, which is endemic in Southern California as well as in Texas and Hawaii, occurred in Los Angeles County in 2022 — the first such fatalities in two decades.
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Major Cardiovascular Event Risk Reduction with Pitavastatin in People Living with HIV
A large randomized, controlled trial (REPRIEVE) conducted by Grinspoon and colleagues showed that in participants living with human immunodeficiency virus (HIV) who are at low-to-moderate risk for cardiovascular disease, those who received pitavastatin had a 35% lower risk of experiencing a major adverse cardiovascular event over a follow-up of approximately five years than those who received placebo.
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Improving Mental and Behavioral Health Among Young Patients
Three national organizations offer recommendations for managing children, adolescents, and young adults in medical facilities and in their communities.
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Endometriosis and the Gut Microbiome: Nutritional Prospects in the Treatment of a Chronic Disease
Endometriosis is characterized by the presence of endometrial glands and stroma in any extrauterine site, such as the ovary, fallopian tubes, pelvic peritoneum, rectovaginal space, bowel, and, rarely, lungs and brain. Standard treatment of endometriosis may involve the use of pain relievers such as nonsteroidal anti-inflammatory drugs, hormonal therapy and modulators, and/or surgical removal of endometriotic tissue. On average, women seek consultation from three different healthcare providers over several years to receive a diagnosis of endometriosis. The delay in care results in significant long-term morbidity.
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NV-HAP: Barriers to Preventing Most Common Hospital Infection
In the pandemic aftermath, with lean resources and nurse staffing in shortfall, there remains this stubborn fact: The most prevalent healthcare-associated infection has no reporting requirements nor well understood incentives to adopt evidence-based prevention practices.
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A Bad Bug in a Burn Unit
As infection control worst-case scenarios go, it does not get much more challenging than a carbapenem-resistant Acinetobacter baumannii outbreak in a burn unit.
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C. auris: Active Screening Interrupts Transmission
The ability for emerging fungal threat Candida auris to move undetected across the healthcare continuum via asymptomatic colonized patients capable of transmitting the pathogen raises a compelling question.